Biosynthesis of N-methyl-l-glucosamine from d-glucose by Streptomyces griseus |
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Authors: | Akiko H Kumagai Nobu Akamatsu |
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Institution: | Department of Biochemistry, St. Marianna University School of Medicine, 2095, Sugao, Takatsu, Kawasaki, Japan |
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Abstract: | Biosynthesis of moiety of streptomycin from d-glucose by Streptomyces griseus was studied. A mixture of d-1-14C]glucose and d-6-3H]glucose was given to the culture of S. griseus. The 3H/14C ratio found in further supports a mechanism that the conversion of d-glucose to l-hexose is carried out without scission of carbon skeleton. When d-1-14C]glucose and d-3-3H]glucose were used, the fall of 3H/14C ratio in showed that the hydrogen atom at C-3 plays a rôle in such a transformation. |
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