Construction of Quaternary Stereocenters: Asymmetric α‐Amination of Branched Aldehydes Catalyzed by Monoimide Substituted Cyclohexane‐1,2‐Diamines |
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| Authors: | Ji‐Ya Fu Qi‐Lin Wang Lin Peng Yong‐Yuan Gui Xiao‐Ying Xu Li‐Xin Wang |
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| Affiliation: | 1. Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, , Chengdu, P.R. China;2. College of Chemistry and Chemical Engineering, Henan University, , Kaifeng, Henan, P.R. China;3. University of Chinese Academy of Sciences, , Beijing, P.R. China |
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| Abstract: | A highly efficient enantioselective α‐amination of branched aldehydes catalyzed by chiral imide monosubstituted 1,2‐diamine derivatives was reported to afford the quaternary stereogenic centers in excellent yields (up to 99%) and enantioselectivities (up to 97% ee). Chirality 25:668–672, 2013. © 2013 Wiley Periodicals, Inc |
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| Keywords: | asymmetric amination branched aldehydes primary amine |
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