cis‐Clerodane Diterpenes from the Liverwort Scapania ciliata |
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Authors: | Na Liu Rong‐Xiu Zhu Song Wang Jiao‐Zhen Zhang Zhao‐Min Lin Rui‐Juan Li Hong‐Xiang Lou |
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Institution: | 1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P.?R. China, (phone: +86‐531‐88382012;2. fax: +86‐531‐88382019) |
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Abstract: | Chemical investigation of the Chinese liverwort Scapania ciliata led to the isolation of four new cis‐clerodane lactones, named ciliatolides A–D ( 1 – 4 , resp.), among which compound 1 was found to be a tetranorclerodanoid. Their structures were determined by extensive analysis of spectroscopic data, and, in the case of compound 1 , together with a single‐crystal X‐ray diffraction analysis. The absolute configurations were established by analysis of the CD spectra and by quantum‐chemical CD calculations. The cytotoxicities of compounds 1 – 4 were preliminarily tested against the PC3 and MCF‐7 cell lines. |
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Keywords: | Liverworts Scapania ciliata Clerodane Diterpenoids Cytotoxic activity |
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