Triterpene Glucosides from the Leaves of Aralia elata and Their Cytotoxic Activities |
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| Authors: | Hai‐Xue Kuang Zhi‐Bin Wang Qiu‐Hong Wang Bing‐You Yang Hong‐Bin Xiao Yoshihito Okada Tohru Okuyama |
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| Affiliation: | 1. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No.?24 Heping Road, Xiangfang District, Harbin 150040, P.?R. China, (phone: +86‐451‐82193001;2. fax: +86‐451‐82110803);3. Meiji Pharmaceutical University, 2‐522‐1 Noshio, Kiyose, Tokyo 204‐8588, Japan |
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| Abstract: | Three new triterpene glucosides, named congmuyenosides C–E ( 1 – 3 , resp.), along with four known ones, were isolated from an EtOH extract of Aralia elata (Miq .) Seem . leaves. The structures of the new compounds were identified as 3‐O‐{β‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→3)‐[β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl}caulophyllogenin ( 1 ), 3‐O‐{β‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→3)‐[β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl}hederagenin 28‐O‐β‐D ‐glucopyranosyl ester ( 2 ), 3‐O‐{β‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→3)‐[β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl}echinocystic acid 28‐O‐β‐D ‐glucopyranosyl ester ( 3 ) on the basis of spectral analyses, including MS, 1H‐NMR, 13C‐NMR, DEPT, HSQC, HMBC, NOESY, and HSQC‐TOCSY experiments. All isolates obtained were evaluated for their cytotoxic activities against three human tumor cell lines (HepG2, SKOV3, and A549). Compound 3 showed significant cytotoxicity against A549 cell line (IC50 9.9±1.5 μM ). |
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| Keywords: | Aralia elata Glycosides Triterpene glucosides Cytotoxic activity Congmuyenosides C – E |
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