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Optical Purifications via Self‐Disproportionation of Enantiomers by Achiral Chromatography: Case Study of a Series of α‐CF3‐containing Secondary Alcohols |
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| Authors: | Alexander E Sorochinsky Toshimasa Katagiri Taizo Ono Alicja Wzorek José Luis Aceña Vadim A Soloshonok |
| Institution: | 1. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, , San Sebastián, Spain;2. IKERBASQUE, Basque Foundation for Science, , Bilbao, Spain;3. Department of Applied Chemistry, Faculty of Engineering, Okayama University, , Kita‐ku, Okayama, Japan;4. National Institute of Advanced Industrial Science and Technology (AIST), , Nagoya, Aichi Prefecture, Japan;5. Institute of Chemistry, The Jan Kochanowski University in Kielce, , Kielce, Poland |
| Abstract: | This work demonstrates that self‐disproportionation of enantiomers via achiral chromatography can be recommended as inexpensive and general method for optical purification of enantiomerically enriched compounds. In particular, the advantage of this approach over conventional recrystallization is that it can be used for both crystalline as well as liquid compounds. Chirality, 25:365‐368, 2013. © 2013 Wiley Periodicals, Inc. |
| Keywords: | fluorine and compounds enantiomeric purification chiral recognition chromatography |