Conformation of hyaluronate in neutral and alkaline solutions |
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Authors: | Martin B Mathews LaVerne Decker |
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Institution: | Departments of Pediatrics and of Biochemistry, The University of Chicago, Chicago, Ill. 60637 U.S.A. |
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Abstract: | Increasing the pH of a neutral salt solution of sodium hyaluronate to 12.5 produces a rapid drop in viscosity which is reversible upon restoring the pH to neutrality. Light scattering data showing a decrease in radius of gyration with no change in molecular weight and negative results with chondroitin and other acidic glycosaminoglycans suggest that the conformational change is specific for hyaluronate molecules. |
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