New Pyran‐2‐ones from Alkalophilic Actinomycete,Nocardiopsis alkaliphila sp. Nov. YIM‐80379 |
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| Authors: | Zhiying Wang Peng Fu Peipei Liu Pei Wang Jiabo Hou Wenjun Li Weiming Zhu |
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| Institution: | 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China (phone/fax: +86‐532‐82031268);2. Key Laboratory for Microbial Resources of the Ministry of Education and Laboratory for Conservation and Utilization of Bio‐Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P.?R. China |
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| Abstract: | Two new pyran‐2‐ones, nocardiopyrones A and B ( 1 and 2 , resp.), along with four known compounds, pyridinols 3 – 5 , and 1‐acetyl‐β‐carboline ( 6 ) were isolated from the alkalophilic actinomycete Nocardiopsis alkaliphila sp. nov. YIM‐80379. Their structures were established on the basis of spectroscopic analysis, CD spectra, and the quantum‐chemical ECD calculation. Pyridinols 3 – 5 were isolated from a natural source for the first time. Compounds 1 and 2 showed weak antibacterial activities against Pseudomonas aeruginosa, Enterobacter aerogenes, and Escherichia coli with MIC values of 20–48 μM . Compound 2 showed weak antimicrobial activities against Candida albicans and Staphylococcus aureus with MIC values of 24 and 48 μM , respectively. |
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| Keywords: | Nocardiopsis alkaliphila Actinomycetes Nocardiopyrones A and B Antimicrobial activity Density‐functional theory (DFT) |
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