首页 | 本学科首页   官方微博 | 高级检索  
   检索      


New Pyran‐2‐ones from Alkalophilic Actinomycete,Nocardiopsis alkaliphila sp. Nov. YIM‐80379
Authors:Zhiying Wang  Peng Fu  Peipei Liu  Pei Wang  Jiabo Hou  Wenjun Li  Weiming Zhu
Institution:1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China (phone/fax: +86‐532‐82031268);2. Key Laboratory for Microbial Resources of the Ministry of Education and Laboratory for Conservation and Utilization of Bio‐Resources, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P.?R. China
Abstract:Two new pyran‐2‐ones, nocardiopyrones A and B ( 1 and 2 , resp.), along with four known compounds, pyridinols 3 – 5 , and 1‐acetyl‐β‐carboline ( 6 ) were isolated from the alkalophilic actinomycete Nocardiopsis alkaliphila sp. nov. YIM‐80379. Their structures were established on the basis of spectroscopic analysis, CD spectra, and the quantum‐chemical ECD calculation. Pyridinols 3 – 5 were isolated from a natural source for the first time. Compounds 1 and 2 showed weak antibacterial activities against Pseudomonas aeruginosa, Enterobacter aerogenes, and Escherichia coli with MIC values of 20–48 μM . Compound 2 showed weak antimicrobial activities against Candida albicans and Staphylococcus aureus with MIC values of 24 and 48 μM , respectively.
Keywords:Nocardiopsis alkaliphila  Actinomycetes  Nocardiopyrones A and B  Antimicrobial activity  Density‐functional theory (DFT)
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号