Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris |
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| Authors: | Natsumi Ishida Hidemasa Nakaminami Norihisa Noguchi Ichiro Kurokawa Setsuko Nishijima Masanori Sasatsu |
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| Institution: | 1. Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432‐1 Horinouchi, Hachioji, Tokyo 192‐0392;2. Department of Dermatology, Nishijima Skin Clinic, 16‐15 Koriminaminochou, Neyagawa, Osaka 572‐0084;3. Department of Dermatology, Graduate School of Medicine, Mie University, 2‐174 Edobashi, Tsu, Mie 514‐8507, Japan |
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| Abstract: | Antibiotic susceptibilities of Propionibacterium acnes in Japan were determined. Erythromycin‐resistance was found in 10.4% (5/48) of the strains, and four of these were cross‐resistance to clindamycin. Although the erythromycin ribosome methylase gene erm(X) was looked for, no strain carrying erm(X) was found. Sequencing analysis revealed that all of the erythromycin‐resistant strains had a mutation in the peptidyl transferase region of the 23S rRNA gene: G2057A, A2058G, or A2059G. Consequently, our results show that P. acnes resistance to macrolides is caused by a mutation in the 23S rRNA gene, and has been increasing in Japan. |
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| Keywords: | acne vulgaris macrolides P acnes 23S rRNA |
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