Inverse correlation between combined mutagenicity in Salmonella typhimurium and strength of coordinate bond in mixtures of cobalt(II) chloride and 4-substituted pyridines |
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| Institution: | 1. Department of Physiology, University of California, San Francisco, CA 94158, USA;2. Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143, USA;6. Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan;1. Department of Health Promotion, School CAPHRI, Maastricht University, Maastricht, the Netherlands;2. Department of Endocrinology and Internal Medicine, School CAPHRI, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands |
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| Abstract: | Cobalt(II) chloride (CoCl2), non-mutagenic by itself, has been tested for mutagenic activity in the presence of 4-substituted pyridines in the test strains of Salmonella typhimurium. CoCl2 was found to be mutagenic in strains TA1537 and TA2637, when combined pyridine, with methyl isonicotinate, 4-methylpyridine, 4-ethylpyridine, 4-chloropyridine or 4-bromopyridine. Mixtures of CoCl2 and isonicotinic acid, 4-cyanopyridine, 4-aminopyridine, or 4-dimethylaminopyridine exhibited no mutagenicity. Judging from the spectral observations, such combined mutagenicity may be due to the formation of moderate to weak complexes between these compounds and the Co(II) cation. |
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