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The pleiotropic gene theory of senescence: Supportive evidence from human genetic disease
Affiliation:1. Department of Anesthesiology Centro Hospitalar São João, EPE, Porto, Portugal;2. Center for Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal;3. Department of Anesthesiology Centro Hospitalar de São João, EPE, Porto, Portugal;4. Oral Surgery, Faculty of Dental Medicine, University of Porto, Porto, Portugal;5. Anesthesiology and Perioperative Care Unit, Department of Surgery, Faculty of Medicine, University of Porto, Porto, Portugal;1. Center for Injury Research and Policy, The Research Institute at Nationwide Children''s Hospital (GA Smith, T Chounthirath), Columbus, Ohio;2. Department of Pedatrics, The Ohio State University College of Medicine (GA Smith, M Splaingard), Columbus, Ohio;3. Child Injury Prevention Alliance (GA Smith), Columbus, Ohio;4. Sleep Disorders Center, Nationwide Children''s Hospital (M Splaingard), Columbus, Ohio
Abstract:Senescence is a universal but poorly understood phenomenon among metazoans. One theoretically convincing but unproven evolutionary theory of senescence is the pleitropic gene theory of Williams (1957). This paper develops the hypothesis that some human genetic diseases exemplify the type of phenotypic effects predicted by this theory. The evidence supporting this contention is reviewed and ways of testing this hypothesis are suggested. Other human genetic diseases could be examined in the same manner. Confirmation of this theory would have significant implications for the study of aging.
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