| Abstract: | The frequency of translocations detected by FISH in lymphocytes of control donors increases with age as a quadratic function.
This process is faster in persons previously exposed to low doses of radiation. It means that translocation frequency can
be used as a measure of biological age. Moreover, translocation frequency should be taken into account in biological reconstruction
of absorbed doses. The frequencies of dicentrics detected by FIGH and FPG linearly increase with age in both groups, and this
process occurs at equal rates during natural and radiation-induced aging. The age-dependent increase in the frequency of translocations
exceeds the increase in dicentrics. The radiation sensitivity of lymphocytes estimated from the frequency of in vitro induced
chromosomal aberrations tends to increase with age in the control group and decreases significantly in the group exposed to
radiation; i.e., low-dose preexposure alters the pattern of the age dependence of radiation sensitivity in lymphocytes in
vitro. |
