Scaffold-Free Tubular Tissues Created by a Bio-3D Printer Undergo Remodeling and Endothelialization when Implanted in Rat Aortae |
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| Authors: | Manabu Itoh Koichi Nakayama Ryo Noguchi Keiji Kamohara Kojirou Furukawa Kazuyoshi Uchihashi Shuji Toda Jun-ichi Oyama Koichi Node Shigeki Morita |
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| Affiliation: | 1. Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga University, Saga, Japan.; 2. Biomedical Engineering Course Advanced Technology, Fusion Graduate School of Science and Engineering, Saga University, Saga, Japan.; 3. Department of Cardiovascular Medicine, Faculty of Medicine, Saga University, Saga, Japan.; 4. Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga, Japan.; North Carolina A&T State University, UNITED STATES, |
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| Abstract: | BackgroundSmall caliber vascular prostheses are not clinically available because synthetic vascular prostheses lack endothelial cells which modulate platelet activation, leukocyte adhesion, thrombosis, and the regulation of vasomotor tone by the production of vasoactive substances. We developed a novel method to create scaffold-free tubular tissue from multicellular spheroids (MCS) using a “Bio-3D printer”-based system. This system enables the creation of pre-designed three-dimensional structures using a computer controlled robotics system. With this system, we created a tubular structure and studied its biological features.ConclusionsThe scaffold-free tubular tissues made of MCS using a Bio-3D printer underwent remodeling and endothelialization. Further studies are warranted to elucidate the underlying mechanism of endothelialization and its function, as well as the long-term results. |
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