Subretinal Fluid in Eyes with Active Ocular Toxoplasmosis Observed Using Spectral Domain Optical Coherence Tomography |
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| Authors: | Yanling Ouyang Fuqiang Li Qing Shao Florian M. Heussen Pearse A. Keane Nicole Stübiger Srinivas R. Sadda Uwe Pleyer |
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| Affiliation: | 1. Charité, University Medicine Berlin, Department of Ophthalmology, Berlin, Germany.; 2. Eye Center affiliated with 2nd Hospital, Jilin University, Changchun, China.; 3. NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.; 4. Doheny Eye Institute and Department of Ophthalmology, Los Angeles, California, United States of America.; Duke University, UNITED STATES, |
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| Abstract: | PurposeTo describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT).DesignRetrospective case series.ParticipantsThirty-eight eyes from 39 patients with active OT.MethodsEyes with active OT which underwent SD-OCT were reviewed. SRFs in the posterior pole were further analyzed.ResultsSRF presented in 45.5% (or 15/33) of eyes with typical active OT and in 51.3% (or 20/39) of eyes with active OT. The mean maximum height and total volume of SRF were 161.0 (range: 23–478) µm and 0.47 (range: 0.005–4.12) mm3, respectively. For 12 eyes with SRF related to active retinal necrosis, SRF was observed with complete absorption after conventional anti-toxoplasmosis treatment. The mean duration for observation of SRF clearance was 33.8 (range: 7–84) days. The mean rate of SRF clearance was 0.0128 (range: 0.0002–0.0665) mm3/day.ConclusionsSRF (i.e., serous retinal detachment) is a common feature in patients with active OT when SD-OCT is performed. The majority of SRF was associated with retinal necrosis and reacted well to conventional therapy, regardless of total fluid volume. However, SRF accompanying with CME or CNV responded less favorably or remained refractory to conventional or combined intravitreal treatment, even when the SRF was small in size. |
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