Conserved sequences in bacterial and viral sialidases |
| |
| Authors: | Peter Roggentin Bernd Rothe James B Kaper James Galen Lois Lawrisuk Eric R Vimr Roland Schauer |
| |
| Institution: | (1) Biochemisches Institut, Christian-Albrechts-Universität, Olshausenstr. 40, D-2300 Kiel, W. Germany;(2) Center for Vaccine Development, Division of Geographic Medicine, University of Maryland, 21201 Baltimore, Maryland, USA;(3) Department of Veterinary Pathobiology, Microbiology Division, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801 Ulbana, Illinois, USA |
| |
| Abstract: | The genes of the bacterial sialidases fromClostridium sordellii G12,C. perfringens A99,Salmonella typhimurium LT-2 andVibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases.Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances betweeen the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9. |
| |
| Keywords: | sialidase sequence homologies Clostridium perfringens C sordellii Salmonella typhimurium Vibrio cholerae Influenza A virus |
| 本文献已被 SpringerLink 等数据库收录！ |
|
