Synthesis and antimicrobial activity of erythromycin-A oxime analogs |
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| Authors: | Pandey Deepa Katti S B Haq W Tripathi C K M |
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| Affiliation: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of erythromycin-A oxime ether as well as esters have been synthesized. Ether derivatives were synthesized through the epoxy ether intermediate of erythromycin-9-oxime, followed by opening of the epoxy linkage through various amines, whereas esters have been prepared through DCC mediated protocol. These derivatives have been evaluated for antibacterial activity and found to be as active as erythromycin-A. |
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