Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection. |
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Authors: | M M Hoq T Suzutani K Nakaya I Yoshida M Ogasawara Y Takeda T Shibaki S Itohara H Yamamoto M Azuma |
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Affiliation: | Department of Microbiology, Asahikawa Medical College, Japan. |
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Abstract: | Normal mice inoculated intravenously with 50 microg trehalose-6,6'-dimycolate, a glycolipid component of the cell wall of Mycobacterium, in an oil-in-water emulsion (TDM emulsion) acquired a high resistance to intranasal lethal infection of an influenza virus. In contrast, TDM emulsion-treated T-cell receptor delta gene mutant (TCR delta-/-) mice acquired insufficient resistance against the lethal influenza virus infection. The patterns of insufficient resistance were identical to the results obtained previously with mice which were depleted of T-lymphocytes bearing gammadelta T-cell receptors (gammadelta T-cells) by in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (Hoq et al, J. Gen. Virol. 78: 1597-1603, 1997). These results strongly suggest that the gammadelta T-cells play an important non-specific role in resistance against influenza virus infection. |
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Keywords: | T-cell receptor δ gene mutant mice (TCR γ / mice) influenza virus trehalose-6,6′-dimycolate |
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