New Photosensitizers of Bacteriochlorin Series for Photodynamic Cancer Therapy |
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| Authors: | A. F. Mironov M. A. Grin A. G. Tsiprovskii A. V. Segenevich D. V. Dzardanov K. V. Golovin A. A. Tsygankov Ya. K. Shim |
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| Affiliation: | (1) Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, ussia;(2) Institute of Fundamental Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia;(3) Korea Research Institute of Chemical Technology, Taejon, 305-343, Republic of Korea |
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| Abstract: | New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into  -hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy. |
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| Keywords: | bacteriochlorin p glutarimides bacteriochlorophyll a bacteriopurpurin photodynamic therapy photosensitizers 3-vinylbacteriopurpurin |
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