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Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Authors:Youwen Zhuang  Peiyu Xu  Chunyou Mao  Lei Wang  Brian Krumm  X Edward Zhou  Sijie Huang  Heng Liu  Xi Cheng  Xi-Ping Huang  Dan-Dan Shen  Tinghai Xu  Yong-Feng Liu  Yue Wang  Jia Guo  Yi Jiang  Hualiang Jiang  Karsten Melcher  H Eric Xu
Institution:1. The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;4. Zhejiang Laboratory for Systems and Precison Medicine, Zhejiang University Medical Center, Hangzhou 311121, China;5. MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou 310058, China;6. Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA;7. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA;8. Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Research Institute, Grand Rapids, MI, USA;9. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;10. State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;11. Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou 310058, China
Abstract:
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  • Keywords:dopamine receptors  D1R  D2R  cryo-EM  Parkinson’s disease  apomorphine  bromocriptine  receptor activation  ligand selectivity  G protein selectivity
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