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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
Authors:Hongling Huang  Peipei Zhou  Jun Wei  Lingyun Long  Hao Shi  Yogesh Dhungana  Nicole M. Chapman  Guotong Fu  Jordy Saravia  Jana L. Raynor  Shaofeng Liu  Gustavo Palacios  Yong-Dong Wang  Chenxi Qian  Jiyang Yu  Hongbo Chi
Affiliation:1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;2. Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;3. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Abstract:
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  • Keywords:T cell memory  metabolic heterogeneity  terminal effector cell  immunometabolism  Notch  GDP-fucose  nutrient signaling  cell cycle exit  systems immunology
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