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The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination
Authors:Florian Wimmers  Michele Donato  Alex Kuo  Tal Ashuach  Shakti Gupta  Chunfeng Li  Mai Dvorak  Mariko Hinton Foecke  Sarah E. Chang  Thomas Hagan  Sanne E. De Jong  Holden T. Maecker  Robbert van der Most  Peggie Cheung  Mario Cortese  Steven E. Bosinger  Mark Davis  Nadine Rouphael  Bali Pulendran
Affiliation:1. Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Department of Medicine, Division of Biomedical Informatics Research, Stanford University School of Medicine, Stanford, CA 94305, USA;3. Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA;4. Department of Electrical Engineering and Computer Sciences and Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA;5. Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA 92093, USA;6. GSK, 1330 Rixensart, Belgium;7. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA;8. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA;9. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA;10. Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA 30030, USA;11. Chan-Zuckerberg Biohub, San Francisco, CA, USA;12. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Abstract:
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  • Keywords:vaccines  systems biology  single cell  influenza  trained immunity  adjuvant  epigenome  innate memory  antiviral immunity  monocyte
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