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Lack of evidence for a role of PIWIL1 variants in human male infertility
Authors:MS Oud  L Volozonoka  C Friedrich  S Kliesch  L Nagirnaja  C Gilissen  MK O’Bryan  RI McLachlan  KI Aston  F Tüttelmann  DF Conrad  JA Veltman
Institution:1. Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands;2. Scientific Laboratory of Molecular Genetics, Riga Stradins University, LV-1007, Riga, Latvia;3. Institute of Reproductive Genetics, University of Münster, Münster, Germany;4. Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany;5. Division of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA;6. School of Biological Sciences, Monash University, Clayton, Melbourne, Australia;7. School of BioSciences, Faculty of Science, The University of Melbourne, Parkville, Melbourne, Australia;8. Hudson Institute of Medical Research, Clayton, Melbourne, Australia;9. Department of Obstetrics and Gynecology, Monash University, Clayton, Melbourne, Australia;10. Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT, USA;11. Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Abstract:
Keywords:PIWIL1  MIWI  HIWI  D-box  male infertility  azoospermia  oligozoospermia  exome sequencing  single molecule molecular inversion probes  piRNA  clinical validity assessment
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