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The bone microenvironment invigorates metastatic seeds for further dissemination
Authors:Weijie Zhang  Igor L. Bado  Jingyuan Hu  Ying-Wooi Wan  Ling Wu  Hai Wang  Yang Gao  Hyun-Hwan Jeong  Zhan Xu  Xiaoxin Hao  Bree M. Lege  Rami Al-Ouran  Lucian Li  Jiasong Li  Liqun Yu  Swarnima Singh  Hin Ching Lo  Muchun Niu  Xiang H.-F. Zhang
Affiliation:1. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA;2. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA;3. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA;4. Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA;5. Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA;6. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;7. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA;8. Department of Systems Medicine and Bioengineering and Translational Biophotonics Laboratory, Houston Methodist Cancer Center, Houston, TX 77030, USA;9. Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA;10. McNair Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Abstract:
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  • Keywords:bone metastasis  disseminated tumor cells  secondary metastasis  epigenomic reprograming  EZH2  stemness  plasticity  evolving barcodes  organ tropism  circulating tumor cells
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