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An early cell shape transition drives evolutionary expansion of the human forebrain
Authors:Silvia Benito-Kwiecinski  Stefano L Giandomenico  Magdalena Sutcliffe  Erlend S Riis  Paula Freire-Pritchett  Iva Kelava  Stephanie Wunderlich  Ulrich Martin  Gregory A Wray  Kate McDole  Madeline A Lancaster
Institution:1. MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK;2. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK;3. Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany;4. Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany;5. Department of Biology, Duke University, Biological Sciences Building, 124 Science Drive, Durham, NC 27708, USA
Abstract:
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  • Keywords:brain  evolution  cell shape  organoids  brain expansion  neuroepithelium  neural stem cells  ZEB2  gorilla  chimpanzee
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