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TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity
Authors:Wenchun Fan  Katrina B Mar  Levent Sari  Ilona K Gaszek  Qiang Cheng  Bret M Evers  John M Shelton  Mary Wight-Carter  Daniel J Siegwart  Milo M Lin  John W Schoggins
Institution:1. Department of Microbiology, UT Southwestern Medical Center, Dallas, TX 75390, USA;2. Green Center for Molecular, Computational, and Systems Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA;3. Department of Biochemistry, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA;4. Departments of Pathology and Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA;5. Department of Internal Medicine, Histo Pathology Core Division, UT Southwestern Medical Center, Dallas, TX 75390, USA;6. Animal Resource Center, UT Southwestern Medical Center, Dallas, TX, USA
Abstract:
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  • Keywords:Enterovirus  Restriction factor  E3 ubiquitin ligase  Antiviral immunity  Viral evolution  Viral pathogenesis
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