首页 | 本学科首页   官方微博 | 高级检索  
     


Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
Authors:Shira Weingarten-Gabbay  Susan Klaeger  Siranush Sarkizova  Leah R. Pearlman  Da-Yuan Chen  Kathleen M.E. Gallagher  Matthew R. Bauer  Hannah B. Taylor  W. Augustine Dunn  Christina Tarr  John Sidney  Suzanna Rachimi  Hasahn L. Conway  Katelin Katsis  Yuntong Wang  Del Leistritz-Edwards  Melissa R. Durkin  Christopher H. Tomkins-Tinch  Pardis C. Sabeti
Affiliation:1. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;2. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA;3. Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA;4. National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA;5. Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA;6. Harvard Medical School, Boston, MA 02115, USA;7. Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA;8. Repertoire Immune Medicines, Cambridge, MA 02139, USA;9. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA;10. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel;11. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA;12. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA;13. Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA;14. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA;15. Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA;16. Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA;17. Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA;18. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA;19. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA;20. Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA;21. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA;22. Health Informatics Lab, Metropolitan College, Boston University, Boston, MA, USA;23. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;24. Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA;25. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA;26. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Abstract:
><ol class=
  • Download : Download high-res image (225KB)
  • Download : Download full-size image
  • Keywords:SARS-CoV-2  out-of-frame ORF immunopeptidomics  T Cell response  immunogenicity  HLA Class I  viral infection  coronavirus
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号