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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Authors:Jin Wei  Mia Madel Alfajaro  Peter C. DeWeirdt  Ruth E. Hanna  William J. Lu-Culligan  Wesley L. Cai  Madison S. Strine  Shang-Min Zhang  Vincent R. Graziano  Cameron O. Schmitz  Jennifer S. Chen  Madeleine C. Mankowski  Renata B. Filler  Neal G. Ravindra  Victor Gasque  Fernando J. de Miguel  Ajinkya Patil  Huacui Chen  Craig B. Wilen
Affiliation:1. Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA;2. Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA;3. Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;4. Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 06520, USA;5. Department of Cell Biology, Yale University, New Haven, CT 06520, USA;6. Chemical Biology Institute, Yale University, West Haven, CT 06516, USA;7. Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA;8. Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA;9. Department of Computer Science, Yale University, New Haven, CT 06520, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;11. Yale Center for Molecular Discovery, Yale University, West Haven, CT 06516, USA;12. Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;13. Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06520, USA;14. Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA;15. Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA;16. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;17. Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
Abstract:
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  • Keywords:SARS-CoV-2  COVID-19  CRISPR screen  HMGB1  SWI/SNF complex  MERS-CoV  Middle East Respiratory Syndrome  Severe Acute Respiratory Syndrome  Epigenetics
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