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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever
Authors:J Maximilian Fels  Daniel P Maurer  Andrew S Herbert  Ariel S Wirchnianski  Olivia Vergnolle  Robert W Cross  Dafna M Abelson  Crystal L Moyer  Akaash K Mishra  Jennifer T Aguilan  Ana I Kuehne  Noel T Pauli  Russell R Bakken  Elisabeth K Nyakatura  Jan Hellert  Gregory Quevedo  Leslie Lobel  Stephen Balinandi  Kartik Chandran
Institution:1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA;2. Adimab, LLC, Lebanon, NH 03766, USA;3. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA;4. Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA;5. Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA;6. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA;7. Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA;8. Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA;9. Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France;10. Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel;11. Uganda Virus Research Institute, Entebbe, Uganda;12. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA;13. Adagio Therapeutics, Inc., Waltham, MA 02451, USA;14. The Geneva Foundation, Tacoma, WA 98402, USA
Abstract:
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  • Keywords:Crimean-Congo hemorrhagic fever virus  CCHFV  nairovirus  bunyavirus  tickborne  emerging virus  viral glycoprotein  monoclonal antibody  human monoclonal antibody  antibody therapeutic
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