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Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota
Authors:Djalma S. Lima-Junior  Siddharth R. Krishnamurthy  Nicolas Bouladoux  Nicholas Collins  Seong-Ji Han  Erin Y. Chen  Michael G. Constantinides  Verena M. Link  Ai Ing Lim  Michel Enamorado  Christophe Cataisson  Louis Gil  Indira Rao  Taylor K. Farley  Galina Koroleva  Jan Attig  Stuart H. Yuspa  Michael A. Fischbach  Yasmine Belkaid
Affiliation:1. Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;3. Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA;4. NIH Center for Human Immunology, Bethesda, MD 20896, USA;5. In Vitro Pathogenesis Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;6. Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA;7. Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK;8. Retroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK;9. Department of Medicine, Faculty of Medicine, Imperial College London, London W2 1PG, UK
Abstract:
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  • Keywords:Staphylococcus epidermidis  microbiota  skin immunity  tissue repair  endogenous retrovirus  high fat diet  keratinocytes  antiretroviral  STING  T cells
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