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Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Authors:Shiqun Zhang  Tara N Edwards  Virendra K Chaudhri  Jianing Wu  Jonathan A Cohen  Toshiro Hirai  Natalie Rittenhouse  Elizabeth G Schmitz  Paul Yifan Zhou  Benjamin D McNeil  Yi Yang  H Richard Koerber  Tina L Sumpter  Amanda C Poholek  Brian M Davis  Kathryn M Albers  Harinder Singh  Daniel H Kaplan
Institution:1. Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA;2. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA;3. Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA;4. Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA;5. Division of Allergy & Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;6. School of Medicine, Tsinghua University, No. 1 Tsinghua Yuan, Haidian District, Beijing 100084, China;7. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410013, China;8. Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15261, USA;9. Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Abstract:
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  • Keywords:skin  Langerhans cell  mast cell  neuroimmunology  Mas-related G protein receptors  MrgprB2  nonpeptidergic neurons  MrgprD  glutamate  kainate receptors
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