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Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
Authors:Olivia M. de Goede  Daniel C. Nachun  Nicole M. Ferraro  Michael J. Gloudemans  Abhiram S. Rao  Craig Smail  Tiffany Y. Eulalio  François Aguet  Bernard Ng  Jishu Xu  Alvaro N. Barbeira  Stephane E. Castel  Sarah Kim-Hellmuth  YoSon Park  Alexandra J. Scott  Benjamin J. Strober
Affiliation:1. Department of Genetics, Stanford University, Stanford, CA 94305, USA;2. Department of Pathology, Stanford University, Stanford, CA 94305, USA;3. Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA;4. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA;5. Genomic Medicine Center, Children’s Mercy Research Institute, Kansas City, MO 64108, USA;6. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;7. Department of Statistics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;8. Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada;9. Rush Alzheimer’s Disease Center, Rush University, Chicago, Illinois 60612, USA;10. Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA;11. New York Genome Center, New York, NY 10013, USA;12. Department of Systems Biology, Columbia University, New York, NY 10032, USA;13. Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital LMU Munich, Munich 80337, Germany;14. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA;15. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA;16. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;17. Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA;18. Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA;19. Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA;20. Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA;21. Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA;22. Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA;23. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA;1. Department of Genetics, Stanford University, Stanford, CA 94305, USA;2. Department of Pathology, Stanford University, Stanford, CA 94305, USA;3. Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA;4. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA;5. Genomic Medicine Center, Children’s Mercy Research Institute, Kansas City, MO 64108, USA;6. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;7. Department of Statistics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;8. Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada;9. Rush Alzheimer’s Disease Center, Rush University, Chicago, Illinois 60612, USA;10. Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA;11. New York Genome Center, New York, NY 10013, USA;12. Department of Systems Biology, Columbia University, New York, NY 10032, USA;13. Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital LMU Munich, Munich 80337, Germany;14. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA;15. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA;16. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;17. Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA;18. Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA;19. Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA;20. Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA;21. Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA;22. Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA;23. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Abstract:
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  • Keywords:long non-coding RNA  lncRNA  expression quantitative trait loci  eQTL  co-expression  complex trait  disease  GTEx  colocalization
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