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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis
Authors:Pritesh Desai  Hana Janova  James P White  Glennys V Reynoso  Heather D Hickman  Megan T Baldridge  Joseph F Urban  Thaddeus S Stappenbeck  Larissa B Thackray  Michael S Diamond
Institution:1. Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;3. Viral Immunity and Pathogenesis Unit, Laboratory of Clinical Microbiology and Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA;4. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;5. US Department of Agriculture, Agricultural Research Services, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, and Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705-2350, USA;6. Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195, USA;7. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA
Abstract:
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  • Keywords:helminth  viral pathogenesis  CD8+ T cells  microbiome  type 2 immunity  IL-4  tuft cells  succinate  flavivirus
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