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The antigenic anatomy of SARS-CoV-2 receptor binding domain
Authors:Wanwisa Dejnirattisai  Daming Zhou  Helen M Ginn  Helen ME Duyvesteyn  Piyada Supasa  James Brett Case  Yuguang Zhao  Thomas S Walter  Alexander J Mentzer  Chang Liu  Beibei Wang  Guido C Paesen  Jose Slon-Campos  César López-Camacho  Natasha M Kafai  Adam L Bailey  Rita E Chen  Baoling Ying  Gavin R Screaton
Institution:1. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK;2. Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK;3. Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;4. Oxford University Hospitals NHS Foundation Trust, Oxford, UK;5. Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK;6. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;7. Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK;8. Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK;9. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK;10. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;11. National Infection Service, Public Health England (PHE), Porton Down, Salisbury SP4 0JG, UK;12. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK;13. Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford OX3 7LE, UK;14. NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK;15. Worthing Hospital, Worthing BN11 2DH, UK;16. Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK;17. Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham ME4 4TB, UK;18. Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK;19. Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan;20. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan;21. Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand;22. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA;23. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, St. Louis, MO 63110 USA;24. Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford OX4 2JY, UK
Abstract:
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  • Keywords:coronavirus  SARS-CoV-2  anti-RBD antibody  receptor binding domain  antibody  immune responses  virus structure
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