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Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Authors:Timothy N Hoang  Maria Pino  Arun K Boddapati  Elise G Viox  Carly E Starke  Amit A Upadhyay  Sanjeev Gumber  Michael Nekorchuk  Kathleen Busman-Sahay  Zachary Strongin  Justin L Harper  Gregory K Tharp  Kathryn L Pellegrini  Shannon Kirejczyk  Keivan Zandi  Sijia Tao  Tristan R Horton  Elizabeth N Beagle  Mirko Paiardini
Institution:1. Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA;2. Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA;3. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA;4. Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA;5. Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA;6. Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA;7. Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA;8. Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA;9. Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA;10. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA;11. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA;12. Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  inflammation  immune activation  baricitinib  nonhuman primate  immunology  pathogenesis
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