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Microbial exposure during early human development primes fetal immune cells
Authors:Archita Mishra  Ghee Chuan Lai  Leong Jing Yao  Thet Tun Aung  Noam Shental  Aviva Rotter-Maskowitz  Edwin Shepherdson  Gurmit Singh Naranjan Singh  Rhea Pai  Adhika Shanti  Regina Men Men Wong  Andrea Lee  Costerwell Khyriem  Charles Antoine Dutertre  Svetoslav Chakarov  KG Srinivasan  Nurhidaya Binte Shadan  Xiao-Meng Zhang  Florent Ginhoux
Institution:2. Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, the Academia, 20 College Road, Discovery Tower Level 8, Singapore 169856, Singapore;3. Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117597, Singapore;4. Department of Mathematics and Computer Science, Open University of Israel, Ra’anana 4353701, Israel;5. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel;6. Department of Reproductive Medicine, KK Women’s and Children’s Hospital, Singapore 229899, Singapore;8. Program in Emerging Infectious Disease, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore;9. Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;10. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Singpore;11. Department of Pharmacotherapy and Pharmaceutics, Institute for Medical Immunology, ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels 1050, Belgium;12. Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, the University of Western Australia, PO Box 7214, 6 Verdun Street, Nedlands, Perth, WA 6009, Australia;13. Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia;14. Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 7610001, Israel;15. Department of Pathology and Centre for Trophoblast Research, Tennis Court Road, Cambridge CB2 1QP, UK;16. OBGYN-Academic Clinical Program, Duke-NUS, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore;17. Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore 119077, Singapore;18. Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China
Abstract:
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  • Keywords:fetal Development  fetal immunity  microbes  bacteria  microbiome  immune priming  immune memory  Tem  Treg
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