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Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Authors:Nathan D. Mathewson  Orr Ashenberg  Itay Tirosh  Simon Gritsch  Elizabeth M. Perez  Sascha Marx  Livnat Jerby-Arnon  Rony Chanoch-Myers  Toshiro Hara  Alyssa R. Richman  Yoshinaga Ito  Jason Pyrdol  Mirco Friedrich  Kathrin Schumann  Michael J. Poitras  Prafulla C. Gokhale  L. Nicolas Gonzalez Castro  Marni E. Shore  Kai W. Wucherpfennig
Affiliation:1. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA;2. Department of Immunology, Harvard Medical School, Boston, MA, USA;3. Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA;4. Broad Institute of MIT and Harvard, Cambridge, MA, USA;5. Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;6. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel;7. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA;8. Department of Systems Biology, Harvard Medical School, Boston, MA, USA;9. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA;10. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA;11. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA;12. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany;13. Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA;14. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;15. Departments of Neurology and Radiation Oncology, Divisions of Hematology/Oncology and Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA;16. Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA;17. Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA;18. Genentech, South San Francisco, CA, USA;19. Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA;20. Gladstone Institutes, San Francisco, CA 94158, USA;21. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA;22. Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA, USA;23. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA;24. Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA 02139, USA
Abstract:
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  • Keywords:CD161  T cells  single-cell RNA-seq  glioblastoma  IDH-mutant gliomas
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