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Synthesis of Benzodioxinopyrroles as selective α2-adrenoceptor antagonists |
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| Authors: | J. Kitchin A. D. Borthwick A. C. Brodie P. C. Cherry A. J. Crame A. J. Pipe P. A. Procopiou M. A. Seaman J. P. Turnbull |
| Affiliation: | J. Kitchin*, A. D. Borthwick, A. C. Brodie, P. C. Cherry, A. J. Crame, A. J. Pipe, P. A. Procopiou, M. A. Seaman,J. P. Turnbull |
| Abstract: | A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective α2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analogue (fluparoxan). |
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