Synthesis of 2,3- or 1,2-unsaturated derivatives of 2-deoxy-2-trifluoromethylhexopyranoses |
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Authors: | Wegert Anita Reinke Helmut Miethchen Ralf |
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Institution: | FB Chemie, Organische Chemie, Universit?t Rostock, Albert-Einstein-Strasse 3a, D-18059 Rostock, Germany. |
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Abstract: | The attempted conversion, by treatment with CsF/TBFA in MeCN, of acetylated derivatives of 2-chlorodifluoromethyl-2-deoxyhexopyranoses into their corresponding 2-trifluoromethyl derivatives was always accompanied by an elimination reaction. Thus, representative educts with the D-gluco- and D-manno-configuration gave derivatives of 2,3-dideoxy-2-trifluoromethyl-D-erythro-hex-2-enopyranose and 1,5-anhydro-2-deoxy-2-trifluoromethyl-d-arabino-hex-1-enitol, respectively. X-ray analyses are given for 1,3,4,6-tetra-O-acetyl-2-chlorodifluoromethyl-2-deoxy-alpha-D-mannopyranose and 4,6-di-O-acetyl-2,3-dideoxy-2-trifluoromethyl-alpha-D-erythro-hex-2-enopyranose. |
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Keywords: | Unsaturated sugars Trifluoromethylated sugars Trifluoromethylated anhydrohex-1-enitols Nucleophilic fluorination Glycals |
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