Plasmid copy number control: a case study of the quasi-steady-state assumption. |
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| Authors: | L A Segel A S Perelson |
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| Affiliation: | Department of Applied Mathematics and Computer Science, Weizmann Institute, Rehovot, Israel. |
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| Abstract: | Perelson & Brendel (1989, J. molec. Biol. 208, 245-255) have proposed kinetic models for the control of plasmid copy number, based on experiments by J. Tomizawa and his associates. The quasi-steady-state assumptions (QSSA) made in the analysis of these models are justified in the present paper, thereby providing an example of how QSSA can provide a powerful and reliable tool in the analysis of biological kinetics. |
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