Bmp signaling: turning a half into a whole |
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Authors: | Kimelman David Pyati Ujwal J |
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Institution: | Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195, USA. kimelman@u.washington.edu |
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Abstract: | In a famous experiment over a century ago, Hans Spemann demonstrated that amphibians have a remarkable ability to compensate for perturbations to the embryo. In this issue of Cell, Reversade and De Robertis (2005) uncover the basis of this phenomenon. They demonstrate that interactions between bone morphogenetic proteins (Bmps) and their inhibitors on both the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan. |
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