Immune response to an allergenic fraction ofSetaria digitata in human filariasis |
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Authors: | M K Beuria Manoj K Das |
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Institution: | (1) Regional Medical Research Centre (ICMR), Nandankanan Road, 751016 Bhubaneswar, India |
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Abstract: | A low molecular weight antigenic fraction has been isolated from saline-soluble extracts of cattle filarial parasiteSetaria digitata. This glycoprotein fraction (Fr III) which appears to have low phosphorylcholine content cross-reacted with infective larval
(L3) antigens ofWuchereria bancrofti. Binding of human chronic filarial serum with L3 antigens could be inhibited partially by Fr III. The fraction elicited immediate cutaneous hypersensitivity reaction in people
living inWuchereria bancrofti endemic regions. The proportion of skin test positive cases was found to be highest in endemic normals in contrast to infected
cases. IgE levels were however not different in chronic filariasis and in endemic normals (or in asymptomatic microfilaraemic
carriers). On the other hand, specific IgG level was considerably enhanced only in chronic filariasis |
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Keywords: | Filarial allergen antibody isotypes Setaria digitata ITH response human filariasis |
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