Circumvention of chemotherapy-induced myelosuppression by transfer of themdr1 gene |
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Authors: | Jan J. B. Boesen Kees Nooter Dinko Valerio |
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Affiliation: | (1) TNO-Medical Biological Laboratory, P.O. Box 5815, 2280 HV Rijswijk;(2) Rotterdam Cancer Institute, P.O. Box 5201, 3008 AE, Rotterdam;(3) IntroGene, P.O. Box 3271, 2280 GG Rijswijk, The Netherlands |
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Abstract: | Drug-induced myelosuppression is a frequent reason for curtailing chemotherapy in cancer patients. Rescue of myelosuppressed patients with autologous marrow transplants is reasonably advanced and permits an increase in the dose of anticancer drugs. Despite this improvement, patients often relapse with drug resistance disease. The human multidrug resistance (mdr1) gene might make it possible to render hemopoietic stem cells resistant to anticancer drugs after transfer of this gene. By introducing resistant stem cells into patients it might be possible to treat these patients repeatedly with otherwise ablative therapy. This review explores the feasibility ofmdr1 gene therapy.Abbreviations MDR multidrug resistance - ABMT autologous bone marrow transplantation - P-gp P-glycoprotein - RCR replication-competent retrovirus |
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Keywords: | P-glycoprotein mdr1 multidrug resistance gene therapy myelosuppression chemotherapy bone marrow transplantation |
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