Inhibition of ERK and JNK Decreases Both Osmosensitive Taurine Release and Cell Proliferation in Glioma Cells |
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| Authors: | Mark J. Belsey Andrew R. L. Davies Harry J. Witchel Roland Z. Kozlowski |
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| Affiliation: | (1) Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK;(2) Faculty of Medicine and Dentistry, University of Bristol, Bristol, BS8 1TD, UK;(3) Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK;(4) Present address: Datamonitor Healthcare, Charles House, 108-110 Finchley Road, London, NW3 5JJ, UK |
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| Abstract: | Cell swelling is associated with the activation of an increase in the osmosensitive taurine release (OTR) rate, which serves to decrease cell volume as part of a process known as regulatory volume decrease. OTR, which is sensitive to many pharmacological agents including anion channel blockers and signalling pathway modulators, has also been suggested to play a role in cell cycle progression. At non-cytotoxic concentrations, the anion channel blocker NPPB (25 μM), the extra-cellular signal-regulated kinase inhibitor PD98059 (50 μM), and the c-Jun NH2-terminal kinase inhibitor SP 600125 (5 μM) each decreased the OTR rate by ≥50%, decreased cell proliferation, and increased G0/G1 cell cycle arrest. |
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| Keywords: | Anion channel Glial cell Cell proliferation Osmosensitive taurine release ERK JNK |
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