Mamu-B*08-positive macaques control simian immunodeficiency virus replication |
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Authors: | Loffredo John T Maxwell Jess Qi Ying Glidden Chrystal E Borchardt Gretta J Soma Taeko Bean Alex T Beal Dominic R Wilson Nancy A Rehrauer William M Lifson Jeffrey D Carrington Mary Watkins David I |
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Affiliation: | Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA. |
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Abstract: | Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers. |
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