Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

Authors:	Lorenzo?F?Sempere Sarah?Freemantle Ian?Pitha-Rowe Eric?Moss Ethan?Dmitrovsky Email author" target="_blank">Victor?Ambros Email author

Institution:	(1) Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA;(2) Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA;(3) Department of Molecular Biology, University of Medicine and Dentistry of NJ, Stratford, NJ 08084, USA;(4) Department of Medicine and Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA;

Abstract:	Background The microRNAs (miRNAs) are an extensive class of small noncoding RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In Caenorhabditis elegans, lin-4 and let-7 miRNAs control the timing of fate specification of neuronal and hypodermal cells during larval development. lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study.

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