An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective |
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| Authors: | Andrea Gumiero Clive L. Metcalfe Emma Lloyd Raven |
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| Affiliation: | a Department of Chemistry, University of Leicester, England, UK
b Department of Biochemistry and Henry Wellcome Laboratories for Structural Biology, University of Leicester, England, UK |
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| Abstract: | The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family. |
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| Keywords: | Heme Peroxidase Substrate Cytochrome c peroxidase Ascorbate peroxidase Horseradish peroxidase |
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