Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults |
| |
Authors: | Stephanie Scarmo Haiqun Lin Erin Welch Paul S Bernstein |
| |
Institution: | a Yale University School of Public Health, New Haven, CT 06520, USA b Departments of Dermatology and Surgery, Yale University School of Medicine, New Haven, CT 06510, USA c Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA |
| |
Abstract: | Carotenoids in skin have been known to play a role in photoprotection against UV radiation. We performed dermal biopsies of healthy humans (N = 27) and collected blood samples for pair-wise correlation analyses of total and individual carotenoid content by high performance liquid chromatography (HPLC). The hydrocarbon carotenoids (lycopene and beta-carotene) made up the majority of carotenoids in both skin and plasma, and skin was somewhat enriched in these carotenoids relative to plasma. Beta-cryptoxanthin, a monohydroxycarotenoid, was found in similar proportions in skin as in plasma. In contrast, the dihydroxycarotenoids, lutein and zeaxanthin, were relatively lacking in human skin in absolute and relative levels as compared to plasma. Total carotenoids were significantly correlated in skin and plasma (r = 0.53, p < 0.01). Our findings suggest that human skin is relatively enriched in lycopene and beta-carotene, compared to lutein and zeaxanthin, possibly reflecting a specific function of hydrocarbon carotenoids in human skin photoprotection. |
| |
Keywords: | Carotenoids Lycopene Beta-carotene Lutein Zeaxanthin Beta-cryptoxanthin Skin |
本文献已被 ScienceDirect 等数据库收录! |
|