Acute exposure to cadmium causes time-dependent liver injury in rats. |
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| Authors: | S Theocharis A Margeli C Fasitsas M Loizidou G Deliconstantinos |
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| Institution: | Department of Experimental Physiology, School of Medicine, University of Athens, Greece. |
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| Abstract: | 1. Serum enzymes activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), after intraperitoneal injection of CdCl2 showed a maximum increase at 12 hours, contrary to the alkaline phosphatase (ALP) that showed a permanent decrease by that time. 2. Cadmium concentration in liver showed an increase at 6 and 12 hours, a decrease at 18, and a re-establishment to the initial values at 24 hours. 3. Liver microsomal membrane fluidity showed an increase at 6 hours followed by a decrease within 24 hours. Free radical generation was decreasing gradually up to 24 hours. 4. Gradually increasing changes were observed from the histological study. |
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