Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development |
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Authors: | Juvvadi Praveen Rao Fortwendel Jarrod R Pinchai Nadthanan Perfect B Zachary Heitman Joseph Steinbach William J |
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Affiliation: | Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. |
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Abstract: | A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus DeltacnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus. |
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