| 脂筏的结构与功能 |
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| 引用本文： | 陈岚,许彩民,袁建刚,潘华珍. 脂筏的结构与功能[J]. 生物化学与生物物理进展, 2003, 30(1): 54-59 |
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| 作者姓名： | 陈岚 许彩民 袁建刚 潘华珍 |
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| 作者单位： | 中国医学科学院基础医学研究所,中国协和医科大学基础医学院,医学分子生物学国家重点实验室,北京,100005 |
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| 基金项目： | 国家自然科学基金重点资助项目(30130070). |
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| 摘 要： | 脂筏是膜脂双层内含有特殊脂质及蛋白质的微区.小窝是脂筏的一种类型，由胆固醇、鞘脂及蛋白质组成，以小窝蛋白为标记蛋白.脂筏的组分和结构特点有利于蛋白质之间相互作用和构象转化，可以参与信号转导和细胞蛋白质运转.一些感染性疾病、心血管疾病、肿瘤、肌营养不良症及朊病毒病等可能与脂筏功能紊乱有着密切的关系.
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| 关 键 词： | 脂筏，小窝，小窝蛋白，信号转导，糖肌醇磷脂-锚固蛋白 |
| 收稿时间： | 2002-09-03 |
| 修稿时间： | 2002-09-03 |
Structure and Function of Lipid Rafts |
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| CHEN Lan,XU Cai-Min,YUAN Jian-Gang and PAN Hua-Zhen. Structure and Function of Lipid Rafts[J]. Progress In Biochemistry and Biophysics, 2003, 30(1): 54-59 |
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| Authors: | CHEN Lan XU Cai-Min YUAN Jian-Gang PAN Hua-Zhen |
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| Affiliation: | National Laboratory of Medical Molecular Biology, Basic Institute of Medical Sciences, The Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China;National Laboratory of Medical Molecular Biology, Basic Institute of Medical Sciences, The Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China;National Laboratory of Medical Molecular Biology, Basic Institute of Medical Sciences, The Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China;National Laboratory of Medical Molecular Biology, Basic Institute of Medical Sciences, The Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China |
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| Abstract: | Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane. Caveolae, a type of lipid rafts, is characterized by high levels of cholesterol, sphingolipids and proteins, and is identified by the presence of the protein caveolin. The structure and component of lipid rafts is used of reciprocity and comformational change between proteins. Lipid rafts are associated with signal transduction and cellar proteins movement. The disfunction of lipid rafts is related to some diseases such as infection, heart disease, cancer, muscular dystrophy and prion protein diseases. |
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| Keywords: | lipid raft caveolae caveolin signal transduction GPI-anchored protein |
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