Effect of parenteral administration of carnitine on liver regeneration in partially hepatectomized rats |
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Authors: | V Bláha J Simek P Zivny L Sobotka Z Zadák |
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Affiliation: | Department of Physiology, Faculty of Medicine, Charles University. |
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Abstract: | Male Wistar rats were subjected to 65-70% hepatectomy and either immediately or 18 h after surgery were given a 6-hour infusion containing 3 ml of either Ringer solution or aqua pro injectione alone or with L-carnitine in doses 8 mg (12.4 mumol), 40 mg (62 mumol) and 200 mg (310.2 mumol)/kg b.w. The rats were killed 6, 18, 24 and 30 h after surgery. The changes in the DNA specific activity and in the mitotic activity demonstrate that L-carnitine has a stimulating, dose-dependent effect on liver regeneration. This effect acts both during early post-hepatectomy, the prereplicative period and in the subsequent replicative period. |
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